Method of Delivery

Project Stealth is researching how attenuated salmonella is a safe and effective method to deliver cancer-fighting drugs directly to the tumor without the side effects traditionally associated with cancer treatments.

Why does it work?

• Salmonella has a unique and natural attraction to cancer cells
• Salmonella can be genetically modified or attenuated to not cause such conditions as “food poisoning.”
• Once attenuated, salmonella can be used to deliver  cancer-fighting drugs directly to tumor sites, disrupting the tumor’s ability to survive

What does this mean?

• Because salmonella delivers cancer fighting drugs directly to the tumor, health cells surrounding the tumor are not affected
• Therefore patients don’t experience the side effects normally associated with cancer drugs
• Meaning it  can be safer for patients and they can tolerate the treatments better than traditional

Mechanism of Action

Project Stealth is based on a mechanism of action that looks at activating the immune system to discriminately fight cancer cells by targeting the entire cancer cell, not just a specific gene or protein within the cell.

• Our body’s immune system has the ability to identify attack and destroy cancer cells.
• When this ability is blocked and/or the amount of cancer cells (cancer cell burden) gets to be too much, the cancer wins and the body loses.

Investigating two approaches

• Project Stealth is investigating two types of molecules that affect the immune system and how they work
  • Some cancer cells block the body’s natural immune system, which prevents the immune system from targeting and destroying cancer cells. Project Stealth is testing the effectiveness of molecules that can reverse this blockade
  • Project Stealth is also testing molecules that boost the immune system’s ability to find and destroy cancer cells (immunostimulatory)

It’s safe and effective

Project Stealth research has already shown:

• 90% reduction in tumor size and weight in a primary tumor model (neuroblastoma)
• 60-90% reduction in tumor size, weight and number in a metastatic tumor model
• Preliminary survival data in dogs who have been diagnosed with osteosarcoma by their veterinarians and referred for treatment is encouraging and will be investigated further

• There have been no noteworthy side effects observed to date using attenuated salmonella.

Why donate?

You can be a catalyst to get this very promising research out of the lab and into the market, so more people with cancer can be treated more effectively and safely.

• Be a part of helping to save more lives sooner by moving this research forward
• 100% of donations go to directly support the research
• Project Stealth has no administrative overhead (unlike many other organizations)